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In fact, patients lose 20.9% (about 22.4 kg) in the first 36 weeks (about 8 months), after which those who continue with Mundjaro lose another 5.5% between weeks 36 and 88

The naltrexone component affects mood pathways too, and bupropion at Contraves dose (360mg/day) is a meaningful psychiatric dose

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Metabolic Enhancement Improves insulin sensitivity and blood sugar control while potentially increasing energy expenditure

As patients lose weight on Mounjaro, many report improvements in various inflammatory conditions

That is a net treatment effect of approximately 5.4%
