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Patient-derived human islets from male and female cadaveric donors were 3D-cultured in solubilised extracellular matrix gel in co-culture with the same donor PBMCs, and incubated with cytokines (IL-1, TNF-, IFN-) for 2448 h in the presence of vehicle or increasing concentrations of the CB1R blocker JD-5037

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This medication has been identified as Zepbound 12.5 mg/0.5 mL injection (single-dose pen) and is used for Obstructive Sleep Apnea/Hypopnea Syndrome, and Weight Loss.

The findings will likely change the standard of care, as this Cancer Currents post explains.

Keren Zhou answers common questions about GLP-1s.