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Gastroenterology 150 , 1147-1159.e1145

This is potentially dangerous and almost certainly counterproductive

Retatrutide dosing protocols after tirzepatide by previous dose level Your previous tirzepatide dose determines not just where you start retatrutide, but how quickly you should escalate and what your target maintenance dose should be

However, the medication discontinuation rates were greater than 50% across all doses compared to 40% with placebo, with the most common adverse events (AE) being gastrointestinal in nature [27]

There have also been documented local skin reactions when using GLP-1 RAs, particularly with the long-acting formulations

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