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[1] [17] Importantly, when used as monotherapy, these medications have a low risk of hypoglycemia

It stimulates production of endothelial nitric oxide (NO), a potent vasodilator, leading to the relaxation of blood vessels and improved coronary blood flow (53, 54)

Common temporary side effects include: Nausea Occasional vomiting Stomach discomfort or fullness These symptoms are usually mild and improve within a few weeks

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The initial dosing starts at 0.25 mg per week and is gradually increased at 4-week intervals to 0.5, 1.0, 1.7 mg, and finally to a maximum dose of 2.4 mg per week