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Takeaway Self-administration with a GLP-1 medication purchased without a prescription is never a good idea for a young athletes

But by week 10, I felt completely normal again

Important MeSH terms and keywords used were: glucagon-like peptide 1 (GLP-1), GLP-1 analogue, incretin, dipeptidyl peptidase 4 (DPP-4) inhibitor, atherosclerosis, arteriosclerosis, atherogenesis, plaque, intima media thickness (IMT), flow-mediated dilation (FMD), adiponectin, leptin, endothelin, E-selectin, resistin, pentraxin, brain natriuretic peptide (BNP), monocyte chemotactic protein (MCP), vascular cell adhesion molecule-1 (VCAM-1), plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), triglyceride and cholesterol

Trial participants who continued Retatrutide through 48 weeks maintained 91% of their weight loss without significant regain

Accessed July 19, 2026

However, for a subset of patients, gastrointestinal symptoms can be persistent and may affect treatment adherence