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As a result, dozens of upstream and downstream neural targets of 5-HT have been identified, revealing a multitude of neural circuits involved in mediating the anorexigenic effect of 5-HT

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Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT): [9] A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity (SURMOUNT-MMO): [10] Trial Finds Bimagrumab Aids Weight Loss in Patients With T2D, Obesity

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The first cohort included 6696 patients who started GLP-1 receptor agonists and added on SGLT-2 inhibitors, and the second included 8942 patients who started SGLT-2 inhibitors and added on GLP-1 receptor agonists