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The cardiovascular effects of tirzepatide were evaluated in the large SURPASS-CVOT trial, which compared tirzepatide directly with dulaglutide (Trulicity) a GLP-1 medication already proven to reduce cardiovascular events
PMCID: PMC11257941
Advances in cryo-electron microscopy imaging of receptor structures, and the ability to create dynamic models to understand how the receptors change shape, are now crucial parts of GPCR drug discovery that allow initial in silico screens
