mechanism of action glp-1 agonist Frontiers Mechanism of action of GLP-1

While specialists see them as a promising tool for metabolic optimisation and improving reproductive readiness, others caution that evidence remains limited, long-term effects are unclear, and nutritional concerns need closer attention

Jay agrees, calling this a modest amount of weight loss

Response rates vary by molecule newer agents such as tirzepatide and semaglutide yield higher responder rates (~86%91%) than older agents such as exenatide or liraglutide (~40%65%) (223) and vary by baseline BMI, sex, and glycemic status, with women and individuals with higher BMI responding better (222, 224)

These studies are earlier stage but reflect the breadth of conditions that share overlapping reward circuitry

"It's a worthwhile discussion for the patient and provider to really think about what is going to help them stay on the medication longer," says Watanabe

If youre considering weight loss support, focus on approaches with clinical evidence and professional guidance rather than products making implausible claims about transdermal delivery