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With the exception of antiretroviral therapy, I cant think of another class of medications where there has been so much buzz, Dr Todd Brown of Johns Hopkins Medicine said during his plenary talk entitled GLP-1 Agonists: Are They a Cure for Everything? He concluded that the enthusiasm is warranted, but there are unanswered questions for people with HIV and global access will be a major challenge. Weight gain and metabolic abnormalities are a growing concern for people with HIV as they age

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Currently, patients have fewer generic alternatives, and most available GLP-1 medications are branded, often resulting in higher costs for consumers

Dr Norman is not advocating for the use of these drugs off-label, and notes that any person taking these drugs should be under the care of a licensed professional who is expert in their use and potential side effects.

These products typically claim to support or stimulate GLP1, but are not supported by randomized controlled trials demonstrating increased GLP1 levels or weight loss or glycemic benefits in humans

Other potential etiologies included constipation, diverticulitis, inflammatory bowel syndrome flare, and epiploic appendagitis