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The FDA prescribing information does not mandate gradual dose reduction

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Since they contain the same active ingredient, semaglutide, these two medications have many of the same side effects

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O., Lee J.-H., Boyanapalli S

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Ozempic Marathon Runners: Comparison Dose, Timeline & Reversibility Key Takeaways Semaglutide reduces skeletal muscle glycogen synthesis by 1020% even when carbohydrate intake is adequate, creating a metabolic bottleneck that endurance performance cannot overcome

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