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These drugs were designed for long-term use, so manufacturers havent provided formal instructions for stopping
As a result, the extent to which observed cerebrovascular benefits represent glycaemia-independent effects versus risk-factor modification in diabetes cannot be fully disentangled

Furthermore, the expansion of the targeted treatments into broader health concerns, such as reducing the risk of dementia, has broadened their appeal
Nature Reviews Neuroscience, 12(11), 685700

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