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Of 125 participants assessed for eligibility, 101 were randomly assigned to semaglutide ( n = 51) or placebo ( n = 50)

doi: 10.1038/s41591-022-01707-4 78 US National Institutes of Health

Endocrine Practice 27(2):8389

The GIP receptor activation adds a complementary mechanism, improving insulin sensitivity and potentially enhancing the metabolic effects beyond what GLP-1 alone achieves

This distinction matters enormously when considering whether rotation between them is safe, effective, or even practical

Its important to remember that communication is key
