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For example, specific trials with semaglutide have reported lean mass losses anywhere from 0% to 40% of total weight lost, though fat loss generally outweighs muscle loss, resulting in a higher proportion of lean mass relative to overall body weight

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Anyone with a BMI score of between 30 and 39.9 is classified as obese (40 and over is in the severely obese range)

5 Conclusion In summary, GLP-1RAs have revolutionized obesity and diabetes management, offering potent weight loss and cardiometabolic benefits, but are best used in conjunction with lifestyle interventions, particularly exercise, to optimize health outcomes and sustainability

Low-fat or non-fat dairy products, like yogurt, milk, and cheese
On 29 January 2026, the MHRA updated product information for GLP-1s and issued a drug safety alert to highlight that acute pancreatitis is a known but infrequent side effect that can be fatal, stressing that patients and clinicians should be alert to initial symptoms, such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting 26