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Procedures such as gastric sleeve or gastric bypass lead to greater average weight loss than medication alone and have demonstrated long-term survival advantage

Lunch: 2530 g protein, vegetables, small whole grain portion

The rate at which weight is regained is 0.3 kg per month faster after discontinuing these drugs compared to weight regain following discontinuation of diets or exercise regimens

Ethics declarations Ethics approval and consent to participate All animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of the Fourth Affiliated Hospital of Harbin Medical University (No.:2025-DWSYLLCZ-76)