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The researchers suggested the benefits of GLP-1s before pregnancy could be negated or attenuated by the adverse effects of GLP-1 discontinuation. They added the higher risk for gestational weight gain may contribute to the increased risk for hypertensive disorders of pregnancy and gestational diabetes given the established relationship between gestational weight gain and adverse pregnancy outcomes. Maya told Healio that many individuals are on GLP-1s before pregnancy and are benefiting tremendously. Clinicians following these patients need to know that when their patients stop these medications for pregnancy, they are at risk for greater gestational weight gain and greater risk for gestational diabetes, hypertensive disorders of pregnancy and preterm delivery, she said

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(Karolina Barto), P.M

[5] This rapid breakdown explains why therapeutic GLP-1 receptor agonists have been chemically modified to resist DPP-4 degradation, thereby extending their duration of action and clinical efficacy in managing diabetes and obesity

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