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Moreover, the optimal model of IF is still unclear, and more research is needed to understand the underlying cellular pathways that are activated during IF compared to caloric restriction [4, 6]

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In our rats, semaglutide administration did not yield weight reduction

Section 2: Mechanism of Action of Semaglutide Semaglutide exerts its pharmacological effects through activation of the glucagon-like peptide-1 (GLP-1) receptor, a key regulator of glucose metabolism and energy homeostasis