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In humans, diastolic dysfunction results from structural and functional changes that increasingly impede diastolic filling after midlife

Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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Common uses include infections of the upper and lower respiratory tract, ears, nose, throat, skin, and some sexually-transmitted infections

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