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Think of it like a key that warps in hot temperatures

Here is a framework for thinking through the decision, based on the dosage and outcome data above

According to the FDA labeling, there is no clinically meaningful difference in absorption between these sites

Hepatic Uncommon (0.1% to 1%): Acute gallbladder disease (cholelithiasis, biliary colic, cholecystectomy) Hypersensitivity Common (1% to 10%): Hypersensitivity reactions (e.g., urticaria, eczema) Postmarketing reports : Anaphylaxis, angioedema Immunologic Very common (10% or more): Anti-drug antibodies (up to 51%) Common (1% to 10%): Neutralizing antibodies Local Common (1% to 10%): Injection site reactions Metabolic Very common (10% or more): Hypoglycemia (up to 19%), decreased appetite (up to 11%) Common (1% to 10%): Hyperglycemia Hypoglycemia (glucose level less than 54 mg/dL) occurred more frequently when this drug was used in combination with a sulfonylurea (up to 13% of patients in a clinical trial)

Medullary thyroid carcinoma (MTC) and MEN2 -- both drugs carry a boxed warning based on rodent thyroid C-cell tumors

How many companies are developing therapies for the treatment of obesity