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2 GLP-1 signaling within hypothalamic circuits of the brain activates satiety-promoting neurons and inhibits hunger-promoting neurons

For patients using GLP-1 medications for type 2 diabetes management , abrupt cessation may lead to deterioration in blood glucose control, particularly if alternative treatments are not immediately implemented

10.1016/S2213-8587(22)00008-0 38 KakuK.RasmussenM

85% of patients achieved more than 5% weight loss compared to 26% on placebo

doi: 10.1038/s42255-023-00811-0

All told, Mounjaro and other medications in the GLP-1 family are thought to help lower your set point: the weight your body naturally settles at due to an interplay of genetics, biology, and environment