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At the indicated time (20 min and 60 min) an aliquot of 70 L was removed from each experimental reaction and pipetting into 175 L of acetonitrile at 0 C to quench the reaction ( t = 0 min was determined using the reaction without plasma)

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Collectively, these findings indicate that ferroptosis contributes to ovarian dysfunction and systemic metabolic disturbances in PCOS through mechanisms involving oxidative damage, metabolic dysregulation, and inflammatory responses

Acknowledging limited human data, the studys lead author Associate Professor Luke Grzeskowiak said the potential risks are concerning