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Chen, J

Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis Published online by Cambridge University Press: 30 November 2023 Abstract Recent reports of individuals experiencing suicidal and/or self-injurious behaviors while using liraglutide and semaglutide have heightened the concerns regarding neuropsychiatric safety of Glucagon-like peptide-1 agonists (GLP-1RAs)

The side effects are caused by the activation of GLP-1Rs in the area postrema of the medulla, which sends signals to the lateral parabrachial nucleus, leading to aversion [9]

After one week of treatment, these side effects begin to disappear

[DOI] [PubMed] [Google Scholar] 620.Sun F., Wu S., Guo S., Yu K., Yang Z., Li L