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This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered

The results indicate that retatrutide has an overall safety and tolerability profile similar to other nutrient-stimulated hormone-based therapies, such as GLP-1 receptor agonists approved for obesity treatment

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Further investigation including a physical exam, stool and blood tests, scans, endoscopy and colonoscopy may be warranted