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Additionally, as patients lose fat mass (which provides insulation), core temperature homeostasis shifts

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doi:10.1148/radiology.166.1.3336673

Rizzo said patients should speak with their doctor if they are concerned about developing the potential health condition

Although its often spoken about as one thing, its consequences look different depending on the organ system involved: Metabolic organs (liver, adipose tissue, pancreas): Chronic inflammation here is associated with insulin resistance, higher glucose, and fatty liver disease. Blood vessels / cardiometabolic system: Inflammation contributes to long-term cardiovascular risk, and GLP-1 therapies improve several cardiometabolic risk factors, including blood pressure. Kidneys: Metabolic stress accelerates kidney damage and albuminuria