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16 However, the burden of gastrointestinal side effects and challenges with long-term adherence limited its broader applicability and underscored the need for more effective and better-tolerated therapeutic alternatives

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Ensuring adequate hydration is therefore an important consideration with GLP-1 RA treatment, as is recommended by the label, particularly for people with renal impairment, as dehydration is known to be associated with renal dysfunction [98]

in many low-to-middle income countries, GLP-1 RAs are available but used by a small fraction who can pay

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