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Prioritize nutrition

MASH is a chronic condition that may require lifelong management

A GIP agonist, ZP6590 (Zealand Pharma) is currently in a phase 1 trial, and a GLP-1/GIP antagonist, maridebart cafraglutide (formerly AMG 133, Amgen) is currently in phase 2 trials
Aizenberg, P

Based at the University of Lausanne in Switzerland, Thorens had a long-standing interest in insulin resistance and diabetes from both an academic and clinical perspective

Preclinical studies have demonstrated that FGF21 could enhance AMP-activated protein kinase (AMPK) signaling, favoring fatty acid oxidation and reducing de novo lipogenesis, which contributes to suppression of fibrosis and improvement of metabolic status 20
