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However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies

Clinically reviewed by Mohammed Ismail Lakhi, MPharm, MRPharmS, Superintendent Pharmacist (GPhC reg

doi:10.1016/j.regpep.2014.04.003 140

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The primary endpoint was major adverse cardiovascular events (MACE), defined as cardiovascular death, nonfatal heart attack, or nonfatal stroke