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Conclusion: While semaglutide is a well-established treatment with proven effectiveness for weight loss and diabetes management, retatrutide appears to offer an innovative approach with potentially higher weight loss efficacy due to its broader hormonal targeting

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This genetic insight helps determine whether a patient is likely to benefit from semaglutide addition to HRT, or whether alternative weight-loss strategies might be preferable

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Falls risk should also be assessed, as rapid weight loss can affect balance and coordination in older adults
