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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously
GLP-1 receptor localization in monkey and human tissue

Starting weight and metabolic health People with higher starting weights often lose more absolute weight in the early weeks, partly because their higher caloric needs create a larger deficit when appetite decreases

2024 Sep;63(9):1128-1130

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Nat Med 19(5):567575 Kolwicz SC Jr, Airhart S, Tian R (2016) Ketones step to the plate: a game changer for metabolic remodelling in heart failure
