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The concern is physiologically plausible
Compliance with Reporting Guidelines: The systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines

Media and Third-Party Validation Major issues This is the weakest point in Willows entire review

Running distance, food intake and body weight were measured daily before dosing of experimental compounds

doi: 10.1056/NEJMoa0804748
When this communication pathway is disrupted, gut motility tends to worsen and digestive symptoms intensify