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N Engl J Med 377:1327

More than 80% of new prescriptions are for patients new to GLP-1 therapy, suggesting the oral formulation is expanding the obesity treatment market rather than displacing existing options

Some describe early satiety (feeling full quickly) or reduced interest in food, particularly high-fat or sweet items

GIPR is expressed on pancreatic beta cells, adipocytes, osteoblasts, and neurons of the hypothalamus

Nutritional approaches tailored to perimenopausal physiology include: Protein optimisation : Moderate protein intake (around 1.01.2 g/kg body weight daily for most women) may help preserve muscle mass and enhance satiety