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Based on these data, an ongoing phase 1/2a, multicenter, open-label, ascending dose, first in-human clinical trial is planned to evaluate the safety of intracisternal PR001A (AAV9-GBA1) administration in patients with moderate to severe PD with at least one GBA pathogenic variant (NCT04127578, Table 2)
Current development stages, associated condition and holding companies (in brackets) are provided (where available) for each
It means one-day adjustments become even less consequential over time
Fats are needed for you to produce hormones, such as estrogen, progesterone, and testosterone
Previous studies have suggested that S109 and T241 are key sites for OGlcNAcylation of YAP
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
