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Pramlintide is the first synthetic amylin analogue that approved for diabetes management with WL up to 7.9% [86]

Endpoints and Assessments For determination of plasma concentrations, blood samples were drawn at 15 min before dosing and at frequent time points after dosing based on the drugs elimination half-lives (Electronic Supplementary Table 1)

When used together under medical supervision, these two therapies can work synergistically to enhance fat loss, stabilize blood sugar, and improve overall body composition

However, clinical practice reveals considerable individual variation in both efficacy and tolerability

Severe dehydration causes dark brown urine