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The central application of GLP-1 receptor agonists potently decreases food intake, likely through GLP-1 receptor (GLP-1R)-expressing targets in multiple brain areas including in the hypothalamus and brainstem (24, 26, 28-30), nuclei also targeted by estrogen (31), supporting a potential interaction

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Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial