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Description
The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for
N Engl J Med 389(12):10691084
However, the DDIs mediated by these factors remain poorly understood and will require further investigation to ensure the safe use of GLP-1 RAs with concomitant medications
Ozempic is manufactured using recombinant DNA technology, making it a man-made product
Probably, but not immediately
The development of new GLP-1RA therapies requires post-marketing safety evaluations and real-world evidence to identify and address potential risks
