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retatrutide vs semaglutide weight loss comparison Lilly orforglipron oral GLP-1 phase 3 trial CagriSema vs Retatrutide 2026: Approval
Description
The explanation here is physiological

There are similar concerns for companies that make much of their money due to the obesity epidemic

2015 Oct 1;21(4):511-9
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Leptin and Peptide YY(3-36) are hormones created respectively in fat tissue and the small intestine, and both facilitate satiety and potentially aid long-term weight reduction [12]

This approach could also better inform optimal patient selection and shared decisionmaking in clinical practice