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Some people experience no gastrointestinal issues with tirzepatide but cannot tolerate semaglutide, or vice versa

The SELECT trial demonstrated a 38% CRP reduction regardless of baseline BMI, statin use, or cholesterol levels
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Efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes in a randomized controlled trial (AWARD-3) Diabetes Care

Notably, no significant difference in albuminuria was observed [82]
