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Compared with a group of people with a similar set of clinical characteristics matched closely on demographic factors such as age and ethnicity, treatment indicators such as average body mass index and diabetes prevalence, history of treatments such as bariatric surgery and prevalence of related comorbidities the analysis found that those on GLP-1s lost about twice as much weight

doi.org/10.1111/dom.16275 3 Neeland IJ, Linge J, Birkenfeld AL

Roughly 30 percent lost at least 20 percent of their starting weight, compared with 3.3 percent taking the placebo

Using both could increase the risk of side effects such as nausea, vomiting, diarrhoea and dehydration, without proven added benefit

In addition, semaglutide helps to reduce the amount of sugar produced by the liver and delays the emptying of the stomach