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Notably, older adults with obesity and preserved baseline muscle mass represent a particularly understudied phenotype, and dedicated studies are needed to determine whether this subgroup may differentially benefit from the muscle quality improvements associated with GLP-1 RA therapy

Many HSAs classify weight management medications differently than diabetes treatments, affecting approval

A study reported that a patient with ASUC, who was undergoing treatment with infliximab, azathioprine, and mesalamine but did not respond to steroids by day 3, received FMT

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Those who may warrant closer monitoring include: Individuals with pre-existing tachycardia or arrhythmias, such as atrial fibrillation or supraventricular tachycardia Patients with hyperthyroidism, which independently elevates resting heart rate Those taking other medicines that may increase heart rate, including sympathomimetics (such as decongestants and stimulants), serotoninnoradrenaline reuptake inhibitors (SNRIs), tricyclic antidepressants, or beta-2 agonists used in asthma management Individuals with a history of heart failure, where even modest increases in heart rate may affect cardiac output and symptom burden though it should be noted that increased cardiovascular risk in this group is based on clinical prudence rather than confirmed harm with GLP-1 receptor agonists Patients receiving higher doses of retatrutide, given the dose-dependent nature of the effect observed in Phase 2 trials Age and baseline cardiovascular health are also relevant considerations