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It has been also postulated that there is interindividual variation in the susceptibility of the metabolic organs (e.g., liver, pancreas) to visceral adiposity (liposusceptibility) and this contributes to the manifestation of insulin resistance and adverse effect of excess fat at variable body mass index (BMI), and in different ethnic groups [17]

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Current evidence suggests that the long-term safety profile of GLP-1 receptor agonists is favorable for most patients who tolerate therapy during the early phases of treatment