lilly glp 1 drug FDA approves Foundayo, an oral GLP-1 alternative to Wegovy and Ozempic GLP-1 weight loss could soon

[DOI] [PubMed] [Google Scholar] 32.Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, et al

These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled

Demand for such drugs is likely to continue to be strong in the future due to rising rates of obesity and interlinked chronic diseases

BloodBrain Barrier (BBB) Protection In cerebrovascular contexts, GLP-1 agonists stabilize BBB integrity by upregulating tight junction proteins and reducing MMP-9 activity, potentially mitigating stroke-related damage and vascular dementia pathology [13]

Other GLP-1 receptor agonists such as liraglutide 3mg (Saxenda) or tirzepatide (Mounjaro, per NICE TA1026) may be considered according to local commissioning arrangements and NICE guidance

* Correspondence: Karuna Rasineni, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers