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Description
The STEP trials are testing semaglutide at the higher dose of 2.4 mg/week (as compared to 1.0 mg/week for the original diabetes indication), specifically for promoting weight loss, regardless of the presence of type 2 diabetes

this ligand is then converted to the Y2-R agonist PYY 3-36 via enzymatic cleavage by DPPIV 69,70

& Rayner, C

Important: US Wegovy pens are single-use auto-injectors and cannot be adjusted

Discontinuation of GLP-1 medications typically results in predictable physiological changes as the pharmacological effects wear off

Conclusions Compared with TZD, GLP-1RA had better effects on liver fat content, body mass index, and waist circumference in overweight or obese patients with NAFLD or NASH
