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Because excess weight is closely linked to insulin resistance, fatty liver disease, sleep apnoea, cardiovascular disease, and progression to type 2 diabetes, weight loss achieved with GLP-1 therapy can have wide-ranging metabolic benefits even before diabetes develops

It was popular, there were 18 million prescriptions in 1996

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Management strategies that work reliably: eating small, cold meals rather than large hot ones

However, the prudent approach for this population is closer monitoring during dose escalation and a lower threshold for seeking medical evaluation if palpitations occur

During clinical trials, the effects of tesofensine are typically assessed over a specific period of time, often several weeks or months, to evaluate its effectiveness for the intended purpose