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For weight management, only semaglutide (Wegovy) and liraglutide (Saxenda) are specifically licensed in the UK, with access typically through specialist weight management services according to NICE criteria

For the experimental group, participants had to be on a maintenance dose (at least 4 weeks, Supplemental Table 1) of a GLP-1RA medication for weight loss

Results do not predict exact medication responsegenetics is one input among manybut may help a provider and patient have a more informed conversation about which GLP-1 agent or dosing approach aligns with the patient's genetic profile

Broadening use beyond diabetes in tackling comorbidities Perhaps most transformative is that GLP-1 therapies are no longer confined to diabetes alone

Addressing Lifestyle Modifications: While GLP-1 drugs may offer a pharmaceutical approach to managing diabetes and obesity, the importance of holistic care involving lifestyle and dietary modifications will remain crucial

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