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After 1 year of follow-up, the mean weight loss from baseline with semaglutide 2.4 mg and tirzepatide was 14.6 and 17.2 kg, respectively, with percent weight loss of 14.1% and 16.5%

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Medications in this approach include modulation of peroxisome proliferator-activator receptors (e.g., pemafibrate, elafibranor), medications targeting farnesoid X receptor axis [obeticholic acid

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