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Sleep changes, anxiety, agitation, or unusual mood shifts should be discussed with a clinician, especially when treatment is started or changed

A 52-week treatment with tirzepatide (5mg, 10mg, or 15 mg) led to a significant MASH resolution without worsening liver fibrosis compared to placebo (Fig.3)

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Microdosing refers to the practice of consuming a low dose of GLP-1 drugs (off-label) instead of the standard therapeutic dose to achieve mild weight loss or appetite benefits with fewer side effects at a lower cost

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