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The mechanism of action is very imbalanced, since while it has a comparable GIP receptor binding affinity to native GIP, the affinity to the native GLP-1 receptor is five times lower [20, 21]

10,30 Biologics offer several key advantages over small-molecule drugs, driven by their unique structural complexity and ability to engage diverse biological targets

However, it has shown significant weight loss results in clinical trials

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both drugs are made by Eli Lilly, and the company has positioned them as complementary rather than competitive: tirzepatide for patients needing maximum weight loss, and orforglipron for patients preferring oral therapy or as a maintenance option after injectable treatment