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Roches oral GLP-1 receptor agonist CT-996obtained in the $2.7 billion acquisition of Carmot Therapeuticsreduced body weight by more than 6% at four weeks versus placebo in a Phase I trial.

The primary results of the SURMOUNT-1 trial indicated that compared to placebo, the drug administered at three doses (5, 10, and 15 mg) reduced both weight and blood pressure in overweight or obese patients with weight-related complications (excluding diabetes), though the analysis of blood pressure was limited

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