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however, their clinical application remains investigational [133]

If additional glycemic control is required, increase the dosage in 0.6 mg increments after at least one week on the current dosage

doi: 10.3389/fnins.2019.01112 9 GaoHZengZZhangHZhouXGuanLDengWet al

Metabolism (1966) 15:8657

Clinical studies assessing GLP-1 responses in normal weight and obese subjects suggest that weight gain may induce functional deficits in GLP-1 signalling that facilitates maintenance of the obesity phenotype
