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Can glucagon-like peptide-1 receptor agonists induce asthma

Well focus on the gut, our immune system and the brain, or more simply whats called the Gut-Immune-Brain axis

We found that prolonged exendin-4-induced insulin secretion was increased in INS-1 832/3 and MIN6B1 cells after treatment with small interfering RNA (siRNA) to silence both -arrestins, and also in human EndoC-H1 40 beta cells lentivirally transduced with -arrestin-1 and -arrestin-2 small hairpin RNA (shRNA) (Fig

N Engl J Med 2019;380:2295-306.ArticlePubMed 47

After the validation process, the developed PBPK model can be used to assess the impact of the mechanism of action on the pharmacokinetics of various victim drugs
