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Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification

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Below is a framework summarizing key efficacy and safety findings that should inform provider-guided treatment decisions

concordance correlation coefficient = 0.86)

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